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Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity – Tumors are complex ecosystems composed of networks of interacting ‘normal’ and malignant cells. It is well recognized that cytokine-mediated cross-talk between normal stromal cell
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Here, we show that the polarity protein par-3 localizes asymmetrically in Schwann cells at the axon-glial junction and that disruption of Par-3 localization, by overexpression and knockdown, inhibits.
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